Getting specialized: presynaptic and postsynaptic dopamine D2 receptors
نویسندگان
چکیده
منابع مشابه
Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors.
Dysfunctions of dopaminergic homeostasis leading to either low or high dopamine (DA) levels are causally linked to Parkinson's disease, schizophrenia, and addiction. Major sites of DA synthesis are the mesencephalic neurons originating in the substantia nigra and ventral tegmental area; these structures send major projections to the dorsal striatum (DSt) and nucleus accumbens (NAcc), respective...
متن کاملInhibition of dopamine release via presynaptic D2 receptors: time course and functional characteristics in vivo.
Most neurotransmitters inhibit their own release through autoreceptors. However, the physiological functions of these presynaptic inhibitions are still poorly understood, in part because their time course and functional characteristics have not been described in vivo. Dopamine inhibits its own release through D2 autoreceptors. Here, the part played by autoinhibition in the relationship between ...
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Presynaptic receptors for dopamine, histamine and serotonin that are located on dopaminergic, histaminergic and sertonergic axon terminals, respectively, function as autoreceptors. Presynaptic receptors also occur as heteroreceptors on other axon terminals. Auto- and heteroreceptors mainly affect Ca(2+) -dependent exocytosis from the receptor-bearing nerve ending. Some additionally subserve oth...
متن کاملGetting past the asterisk: the subunit composition of presynaptic nicotinic receptors that modulate striatal dopamine release.
Nicotinic acetylcholine receptors (nAChRs), despite wide distribution, do not play a major role in direct mediation of central synaptic transmission. Instead, these receptors are primarily involved in modulating the release of neurotransmitters, including glutamate, GABA, norepinephrine, dopamine, and acetylcholine itself (Role and Berg, 1996; Wonnacott, 1997). Modulation of dopamine release wi...
متن کاملFunctional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase.
Dihydrexidine (DHX), the first high-affinity D(1) dopamine receptor full agonist, is only 10-fold selective for D(1) versus D(2) receptors, having D(2) affinity similar to the prototypical agonist quinpirole. The D(2) functional properties of DHX and its more D(2) selective analog N-n-propyl-dihydrexidine (PrDHX) were explored in rat brain and pituitary. DHX and PrDHX had binding characteristic...
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ژورنال
عنوان ژورنال: Current Opinion in Pharmacology
سال: 2009
ISSN: 1471-4892
DOI: 10.1016/j.coph.2008.12.002